TERMS AND CONDITIONS OF USE OF THE PARK RESERVATION SYSTEM A Temporary Annual Pass does not qualify for these tickets. Presentation of the definitive Annual Pass is mandatory in order to buy Privilege tickets. If the number of privilege tickets available to the Annual Pass member is exceeded, the transaction will be refused and the price of the 1-day ticket at the entrance to the Disney Parks will be applied with the -20% Annual Pass discount. If the Annual Pass member also wishes to enter the Disney Parks with his companions, he must book his visit via the online reservation platform. The Annual Pass member must be present at the counter during the transaction. The booking confirmation must be presented at the Walt Disney Studios Park ticket offices by the Annual Pass member in order to purchase their Privilege tickets, which are only valid on the day of purchase. The usual sales conditions will apply at the time of purchase (5 tickets maximum per calendar week), and the number of privileged tickets purchased will then be deducted from the total number defined per Annual Pass (maximum 10 tickets for the Magic Plus Annual Pass, 20 tickets maximum for the Infinity Annual Pass). A confirmation of the reservation will be sent by e-mail. Once logged in, the Magic Plus / Infinity Annual Pass member will be able to select the date of visit and the quantity of Privilege tickets desired (subject to availability). "Billets privilèges" will be available for purchase at the counters of the Walt Disney Studios Park, only by prior reservation via the Annual Pass website: Want to offer Billets Privilèges : 1-Day/2-Parks tickets to your family and friends, included in the Magic Plus and Infinity Annual Passes? We encourage to come and check it out regularly. Important: please check the visit dates authorised for your ticket or Annual Pass before you arrive.Īvailability on our reservation system changes frequently. Simply present your Magic Pass (provided at the hotel reception) at the Disney Parks entrance. If you are staying in a Disney Hotel or Village Nature Paris, you do not need to register in advance. You can register a new visit date, either when the first visit date has passed, or if you decide to cancel one of your 3 reservations. You will need to be ready to show your registration confirmation e-mail as well as your Annual Pass to be able to access the Disney Parks on the day (subject to availability).Īnnual Pass members can make up to 3 reservations each at any one time. It’s easy to register! Simply enter your Annual Pass number and choose the dates of your visit. You have to register your Pass on the date(s) of your choice on our dedicated online registration tool. Registration will be mandatory for any Annual Pass. It didn't take long for Disney Infinity to dominate the toys-to-life market, overcoming Skylanders last year and remaining the market leader even after LEGO Dimensions debuted with its equally impressive licensed properties (which includes Jurassic World, Ghostbusters, Back to the Future, Doctor Who, DC Comics, Lord of the Rings, and may more).The general subscription conditions of the Annual Passes do not guarantee access to the Disney Parks when the Parks are at full capacity. It's a shocking revelation, especially given how Disney Infinity helped turn around Disney's gaming efforts (which had previously resulted in major losses), but we now have a better of idea of how and why this all happened when it did. Going forward, Disney will license out its properties to mitigate risk similar to how they currently do with its Star Wars IP. Earlier this week, that potential future was obliterated when seemingly out of nowhere Disney cancelled Disney Infinity, shutdown developer Avalanche Software, stopped its toy production, and basically put an end to their own gaming division.
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The above splicing operation is valid on the premise that all video files have the same format encoding, if you need to splice different formats of video files can use the following scriptĮxtra_options= '-vcodec libx264-crf 23-preset medium-acodec aac-strict experimental-ac 2-ar 44100-ab 128k ' Printf "file '%s ' \ n"./*.$2 > Temp_list.txtįfmpeg-f concat-i temp_list.txt-c Copy output.$2 $fileTypeįor f in./*.$2 Do echo "file ' $f '" > Temp_list.txt Done #cut/join videos using ffmpeg without quality lossĮcho "usage:$0 C seconds < File> "Įcho "eg.Since no recoding is required, these two commands are almost instantaneous.įor convenience, I wrote a script to simplify the operation. The stitching is a little more complicated and we need to keep the video files that need stitching in the following format in a list list.txt:įfmpeg-f concat-i **list.txt**-C copy Output.mp4 The Start_time/stop_time format can be written in two different formats: In fact, with the help of ffmpeg, we can accomplish such tasks without video recoding:įfmpeg-i input.mp4-ss **start_time**-t **stop_time**-acodec copy-vcodec copy Output.mp4 can achieve the cutting/splicing of video files of various tools, but often need to do video transcoding, which inevitably brought the loss of video quality, not to mention that long heinous conversion time. The use of downloadhelper/downthemall such tools to download is often the split file. Online video sites now tend to split a video file into n segments to reduce traffic consumption. It's a GUI made for split audio/video files, using FFMPEG.Cutting/stitching video files is a common requirement. If you want to trim the clip without re-encoding the video, use LosslesCut.
Both have yielded smaller molecules that possess most of the desirable features of MAbs (e.g., antigen specificity and binding) but lack many of the limitations mentioned above. Such platforms can be divided into two major groups: antibody-derived and nonantibody-derived protein scaffolds. Finally, the complex molecular structure of MAbs typically renders them thermally unstable, which requires that they be stored at refrigeration temperatures to ensure stability and clinical efficacy ( 5).īecause of such limitations, scientists over the past 10–15 years began to develop novel and alternative MAb engineering platforms. In some cases, MAbs are unable to bind to epitopes on the surface of protein targets that are accessible only by smaller-sized molecules ( 8). That can reduce their effectiveness in treating some types of cancers (e.g, solid tumors). Third, most MAbs (because of their large size) are limited in their ability to penetrate and accumulate in tissues. Second, their large size (150–160 kDa) makes them unsuitable for most intracellular therapeutic targets, so MAbs must be delivered to patients by injection or infusion ( 7). That process can be extremely labor intensive and costly ( 6). First, their complex molecular structure (four polypeptide chains - two light and two heavy), glycosylation of heavy chains, and at least one disulfide bond in each of several immunoglobulin domains require that full-size antibodies be manufactured in eukaryotic or mammalian expression systems (e.g., CHO cells). Some Clinical Limitations of Therapeutic MAbsĪlthough MAbs are one of the biotechnology industry’s greatest commercial successes to date, they possess several characteristics that can limit their utility and clinical effectiveness ( 4, 5). Currently, ~70 chimeric and humanized MAbs and 30 fully human MAbs are in various stages of clinical development worldwide ( 2). To that point, Humira (Abbott) - one of the first fully human MAbs to be marketed as a treatment for rheumatoid arthritis and other chronic inflammatory indications (Table 1) - is one of the world’s top-selling drugs with sale projected to exceed $9.3 billion in 2012 alone ( 3). Such investments - coupled with major advances in MAb engineering technology - led to development of fully-human MAbs (molecules that contain only human antibody protein sequences).įully human MAbs generally exhibit improved therapeutic efficacy and possess fewer side effects (better safety profiles) than chimeric or humanized MAbs. The commercial success of those early products prompted huge investments by pharmaceutical and biotechnology companies in therapeutic MAb drug development. KEYWORDS: ANTIBODY FRAGMENT ANALYSIS FLOW CYTOMETRY, IMMUNOHISTOCHEMISTRY RADIOLABELING PROTEIN FUSION WHO SHOULD READ: PRODUCT DEVELOPMENT, ANALYTICAL PRODUCT FOCUS: MONOCLONAL ANTIBODIES, FRAGMENTS, AND OTHER PROTEINS Since their introduction, many of those products - including Remicade, Enbrel, and other drugs - have attained blockbuster status. The first MAbs to be commercialized in the early 2000s were chimeric MAbs (genetically engineered hybrid molecules containing murine and human sequences) and “humanized” MAbs (containing 90–95% human antibody protein sequences). Table 1: Commercialized monoclonal antibodies in the United States and European Union () Now, bear with me, I'm not making this post without reading any of the post before me. As an Amazon Associate, we earn from qualifying purchases.Hello everyone, recently I've been lurking these forums trying to find some good book series to start working my way through, and I've decided to make my own post to see if I can find some series with all (or at least, most of) my preferences. If you’re looking to read more in this genre, then check out this space-themed addition for trope rec Tuesday. The sci-fi romance genre is as vast and endless as the space it’s set in: full of niche tropes, high-flying love interests, and scenarios that explore the limits of the human mind. Find a Love Story That Is Out of This World That said, it ends in a cliffhanger due to its series status. I really loved this novel for its plot and its pacing, and how it wove together elements of horror and sci-fi and romance. Over the course of their adventure into the alien vessel, however, they grow close. The person to recruit her is a hotshot astronaut whom she initially clashes with. Jane Holloway: a brilliant linguist who is abruptly recruited for a mission to decipher the language on board the ship. Set in the near future when humanity has discovered a derelict alien ship floating in the asteroid belt, FLUENCY follows Dr. However, it’s a great intro for this genre, to see if it’s for you. Like MACHINATIONS, this book is the first in a series and technically a sci-fi with a romantic subplot. Last on this list for space-bound love stories, I’m going to recommend FLUENCY. That said: I haven’t read the rest of the series, so I can’t speak to its final HEA. Heavy on the angst, but with a great conclusion, MACHINATIONS is perfect for anyone who reads a lot of sci-fi and wants to check out a romance novel instead. Amidst all this, the killer robots have come back for round two. Unfortunately for Rhona, Camus is still mourning her death, and he sees her as an imposter for the woman he loved. With her old memories intact, Rhona wants nothing more than to reintegrate into her previous life and rekindle her relationship with Camus: her second-in-command and erstwhile lover whose connection with her was tragically cut shut. After she is revived, she discovers things are the same, but not quite. The first in a series, MACHINATIONS follows Rhona: a resistance leader brought back from the dead during a robot rebellion. It’s also one of my favorite sci-fi books that I’ve read this year. That said, it’s an easy way to dive deeper into the mash-up arena. MACHINATIONS is technically a sci-fi novel with a romantic subplot instead of a capital R romance. There, they strike a bargain to humiliate Zeus.Įxtremely hot and heavy, NEON GODS is a recent release and a good starting point for the genre.Ĭontent Warnings: Implied domestic abuse, implied off-page sexual assault, on-page dubious consent involving secondary characters. Fleeing across the river, she runs into Hades. Persephone knows that if she marries him, she’ll be next, so she runs away. When Persephone is sold to Zeus in marriage in order to secure an alliance, she panics the man is a modern-day Bluebeard, surrounded by a string of dead wives. The Thirteenth House, overseen by Hades, is on the other side of the river, dividing the metropolis in half. In this story, all inhabitants in the city are ruled over by Thirteen Houses that come with inherited titles. Set in a high-tech, glittering, futuresque city, NEON GODS retells the tale of Hades and Persephone in a very explicit fashion. Despite this, I’m going to make the case that it still belongs as a sci-fi romance book. NEON GODS is an interesting inclusion for this list, in that it’s probably as soft on the sci-fi side of things as one can get. There may be missing content warnings attached. Simultaneously, Silver begins to exert his own boundaries, too.Ī small note of caution: It’s been more than a few years since I’ve read this novel, and my mind is fuzzy on the details. Meanwhile, she grapples with the concept of consent and what it means to be human. Hungry for the kind of unconditional love only a machine can give, Jane runs off with Silver and away from her opulent existence. She finds her chance in Silver, a robotic entertainer who is brought to a luxury party as a gift. Devoid of true affection from the people around her due to her status, Jane is desperate for a real, tangible connection. The first novel in a series written by the legendary Tanith Lee, THE SILVER METAL LOVER follows Jane, a sixteen-year-old girl who lives a pampered life. Although it’s an older story, it remains one of my favorites to this day. This book was one of the first sci-fi novels I ever read. |